BALI – Biophysics Analysics and Ligands

The BALI team studies the biophysics of nucleic acid folding and the targeting of peculiar structures (G-quadruplexes, i-motifs, etc.) by small molecule bioactive ligands. The pharmacochemistry group is specialized in ligand synthesis. The approaches developed also serve for the characterization of other biomolecular interactions, synthetic supramolecular complexes, or biopharmaceuticals (protein or nucleic acid therapeutics).

Pharmacochemistry

The Pharmacochemistry group develops the organic synthesis of new bioactive heterocyclic molecules, which are potential G-quadruplex ligands. One of the main objectives is to conceive, synthesize and evaluate new antiparasitic and anticancer drug candidates.

Themes:

• Heterocyclic chemistry
• G-quadruplex ligands
• Anticancer and antiparasitic drug synthesis

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